CNS Pharmacology MCQs for jobs test preparation in pharmacology departments.
CNS Pharmacology MCQs
Which of the following drugs is least efficacious in the treatment of cemporal lobe epilepsy ?
A. Phenobarbitone
B. Phenytoin sodium
C. Primidone
D. Carbamazepine
Morphine is contraindicated in all of the following except _____?
A. Pulmonary oedema
B. Emphysema
C. Bronchial asthma
D. Head injury
Which of the following is not a contraindication in the therapy with opioids ______?
A. Use in head injury patient
B. use in impaired pulmonary function
C. Use of agonist with mixed agonist-antagonist
D. Use in severe constant pain
Which of the following can be given safely to a patient of congestive heart failure _____?
A. Aspirin
B. Paracetamol
C. Diclofenac sodium
D. Ibuprofen
Which of the following is an irreversible side enact resulting from long term administration of phenothiazline antipsychotics ______?
A. Infertility
B. Parkinsonism
C. Tardive dyskinesia
D. B & C
Which of the following is a nonsteroldad anti inflammatory agent with a tendency to produce blood dyscriasis ?
A. Indomathecin (indocin)
B. Ibuprofen (Motrin)
C. Ketoroloc
D. Aceteminophen
Amyl nitrate is most commonly administered ______?
A. Intravenously
B. By inhatation
C. Sub lingually
D. Orally
Which of the following anti-epileptic agents causes the reversible side-effect of gingival hyperplasia ?
A. Ethosuximide
B. Phenobarbitone
C. Sodium valporate
D. None of the above
Less gastrointestinal bleed is seen in the following NSAID _____?
A. Meloxicam
B. Naproxen
C. C0X2 specific inhibitors
D. Ibuprofen
Aspirin is contraindicated in _____?
A. MI
B. Angina
C. Peptic ulcer
D. Hypertension
Pregnant patient can be safely given _____?
A. Tetracycline
B. Paracetamol
C. Metronidazole
D. Barbiturates
Which of the following anti inflammatory drug is a COX-2 inhibitor _____?
A. Aspirin
B. Ketoprofen
C. Rofecoxib
D. Sulidec
A patient on 300 mg of aspirin will show all the following except _____?
A. Irreversible inhibition of cyclooxygenase path way
B. Prolonged bleeding time
C. Inhibition of thromboxane TXA2
D. Inhibition of prostaglandin PGI2
Salicylate overdose in children causes ___?
A. Crystalluria
B. Rye’s syndrome
C. Kernicterus
D. None of the above
Prolonged use of aspirin causes ______?
A. Hypoprothrombinemia
B. Hyperprothrombinemia
C. Hyprphosphatasia
D. Hypercalcemia
Which of the following drug is used to counter act the gastric irritation produced by administration of NSAID ____?
A. Roxatidine
B. Pirenzipine
C. Betaxolol
D. Misoprostol
NSAID’s have adverse effect on _____?
A. Bone
B. Kidney
C. Liver
D. Stomach
Aspirin acts on which part of brain ?
A. Substantia gelatinosa
B. Limbic system
C. Medulla
D. Cortex
IV ultrashort acting barbiturate ______?
A. Meprobamate
B. Pentobarbitone
C. Thiopentone
D. Phenobarbitone
The intramuscular administration of 0.6 mg of atropine sulphate to a 50 kg adult may produce all of the following effects except ______?
A. Bradycardia
B. Decreased salivation
C. Decreased sweating
D. Mydriasis
Drug which causes gingival hyperplasia _____?
A. Nifedipine
B. Erythromycin
C. Cyclosporin
D. Aspirin
E. Both A & C
One of the benzodiazepines (BDZ) comparatively safe in pregnancy is (Category-B) ?
A. Alprozolam
B. Zolpidem
C. Lorazepam
D. None of the above
An attack of migraine can be easily terminated by ___?
A. Acetylcholine
B. Ergotamine
C. Morphine
D. Ibuprofen
Morphine a powerful opioid analgesic drug should be avoided in all the following conditions except _____?
A. Left ventricular failure
B. Bronchial asthma
C. Constipation
D. A & C
Carbamazepine is a type of _____?
A. Antidepressant
B. Antinflammatory
C. Antibiotic
D. Antiemetic
A 50 year old female with end stage renal disease (ESRD) develops pulmonary tuberculosis. Which one of the following drugs should be used in a reduced dose ?
A. Rifampicin
B. Isoniazide
C. Pyrazamide
D. Ethambutol
One of the obious consequences of alchol ( ethenol), ingestion in many individual is facial flushing and increased heart rate triggered off by alcohol getting metabolized to _____?
A. Formaldehyde
B. Acetaldehyde
C. Propanaldehyde
D. Butanaldehyde
Acute Barbiturate poisoning results in _______?
A. Renal failure
B. Liver failure
C. Respiratory failure
D. Convulsions
NSAID which undergoes enterohepatic circulation ____?
A. Phenylbutazone
B. Piroxicam
C. Aspirin
D. Ibuprofen
An antiepileptic drug used in petitmal epilepsy is ______?
A. Phenobarbitonse
B. Dilantoin sodium
C. Diazepam
D. Ethosuximide
The principle central action of caffeine is on the _____?
A. Cerebral cortex
B. Corpus callosum
C. Hypothalamus
D. Spinal cord
Which of the following is a non steroidal anti inflammatory agent with a tendency to produce blood dyscrasias ?
A. Ibuprofen
B. Indomethacin
C. Aspirin
D. B & C
Salicylate administration is contraindicated in pregnancy because ____?
A. It delay onset of labour
B. Causes pulmonary hypertension of newborn
C. Readily croses placental barrier
D. All of these
Platelet aggregation in inhibited by all except _____?
A. Indomenthacin
B. Salicylates
C. Dypyradimole
D. Phenobarbitone
An untoward effect of that is common to all phenothiazines is ____?
A. A marked increase in blood pressure
B. Rigidity and tremor at rest, particularly with prolonged use
C. Suppression of prolacin
D. Nausea
The first choice of drug for patitmal seizure is ______?
A. Phentoin sodium
B. Carbamazepine
C. Phenobarbitone
D. None of the above
Respiratory depression is seen with ____?
A. Tranquilizers
B. Non-barbiturates
C. Synthetic narcotics
D. Antidepressants
A patient with grandmal epilepsy would likely be under treatment with ____
A. Meprobamate
B. Pentobarbital
C. Trimethadione
D. Phenytoin
Buprenorphine acts by following mechanism ______?
A. Mu receptor antagonist
B. Kappa receptor antagonist
C. Mu receptor partial agnoist
D. Kappa receptor partial agonist
All are symptoms of opiate withdrawls except ____?
A. Diarrhea
B. Lacrimation
C. Mydriasis
D. Excessive speech
Which one of the following muscle relaxant has the maximum duration of action ?
A. Atracurium
B. Vecuronium
C. Rocuronium
D. Doxacurium
The statement Not true of Selective Cox – 2 inhibitor is ______?
A. The analgesic and anti-inflammatory effects identical to that of Non-selective NSAID
B. They do not offer the cardio protective effect
C. Safe in patients with renal insufficiency
D. Fewer incidence of gastrointestinal side effect
Drugs like barbiturates precipitate symptoms of prophyria because _____?
A. They depress ALA synthase
B. They inhibit ALA synthase
C. They induce heme oxygenase
D. They inhibit heme oxygenase
Which of the following is true about parasympathetic nervous system ?
A. Ach is transmitter at both pre & post synaptic junction
B. It causes dilatation of skeletal muscles
C. Post ganglionic fibres are longer than pre ganglionic fibres
D. Noradrenalin is the neurotransmitter at post ganglionic junction
BEnzodiazepines are true in ______?
A. Produce distortion in sleep more than other sedatives
B. More safe than other sedatives when take in larger amounts
C. After metabolism of other drugs in liver
D. All have metabolically active substrates
Which one of the following is NOT an ergot alkaloids _____?
A. Bromocriptine
B. Lysergic acid diethylamide (LSD)
C. Ketanserin
D. Methysergide
Benzodiazepine antagonist is ____?
A. Flumazenil
B. Furazolidone
C. Naloxone
D. Naltrexone
Atypical Antipsychotic are all except _____?
A. Olanzepine
B. Clozapine
C. Risperidone
D. Thioridazone
Which one of the following NSAIDs has adverse effects on liver ?
A. Acetaminophen
B. Aspirin
C. Ibuprofen
D. Diclofenac Sodium
Which of the following drug induces parkinsonism ?
A. Chlorpheniramine
B. Chlorpromazine
C. Chloroquine
D. Chlorhexidine
Following analgesic combination should be avoided ?
A. Aspirin and Codeine
B. Paracetamol and Dextropropoxyphene
C. Ibuprofen and Paracetamol
D. Ibuprofen and DIclofenac
All NSAIDs block cycloxygenase and ____?
A. Prostaglandin synthesis
B. Ectoglandin synthesis
C. Preglandin synthesis
D. Costaglandin synthesis
True about use of midazolam over diazepam is sedation in all except ?
A. Less thrombophlebitis due to low solubility in blond
B. More plasma binding and less toxicity
C. More potent than diazepam
D. Binds to benzodiazepine receptors with 3-4 time more avidly
Aspirine cause _______?
A. Increase BT
B. Increase CT
C. Increase PTT
D. Increase APTT
Shortest acting opioid analgesic is ______?
A. Morphine
B. Fentanyl
C. Remifentanil
D. Sufentanil
All are true of diazapenes except ______?
A. Benzodiazepam is used in treatment of status epilepticus
B. Benzodiazepam is used in the long term treatment of psychic disorders
C. Clonazeppam is used in the treatment of petitmal epilepsy
D. None of the above
Aspirin produces all of the following effects except _____?
A. Frank gastric bleeding
B. Prolonged prothrombin time
C. Platelet dysfunction
D. Constipation
A paralyzing dose of succinylcholine initially elicits _____?
A. CNS stimulation
B. Muscle fasciculation
C. CNS depression
D. Decreased salivation
A common side effect associated with all NSAID drugs is ______?
A. Drowsiness
B. Gastric irritation
C. Xerostomia
D. Constipation
Verril’s sign is seen in ______?
A. Diazepam administration
B. Digitalis toxicity
C. Paget’s disease
D. Unconscious states
Neusea and vomiting that are associated with administration of opioid analgesic is the result of stimulation of the _______?
A. Limbic system
B. Emetic system
C. Chemoreceptor trigger zone (CTZ)
D. Opioid receptors in G.I.T
Narcotic overdose can be antagonized by ____?
A. Diphenhydramine
B. Atropine
C. Naloxane
D. Nalorphine
An attack of bronchial asthma is most likely to be triggered by _______?
A. Aspirin
B. Ibuprufen
C. Diclofenac potassium
D. Mefenamic acid
E. Both A & B
The most prominent toxic effect associated with acetominophen use is ____?
A. Respiratory alkalosis
B. Haemorrhage
C. Hepatic necrosis
D. Gastric Ulceration
Aspirin is avoided in children with influenza infection because of association ____?
A. Reye’s syndrome
B. Nausea
C. Diarrhoea
D. Acid-base imbalance
All of the following statements about pain are correct except _____?
A. Analgesia is associated with μ and k receptors
B. Dysphoria is associated with S receptors
C. NSAIDS benefit by preventing prostaglandin synthesis
D. Naloxane is a non-competitive antagonist and irreversibly opposes the opioids
Which of the following opioids is not given intrathecally ?
A. Remifentanil
B. Morphine
C. Sufentanil
D. Fentanyl
Antagonist of morphine is _____?
A. Naloxone
B. Nalosphine
C. Nalpuphine
D. Methadine
Aspirin is used in treatment of Myocardial Infarction _____?
A. It inhibits thromboxanes
B. It stimulates Prostacyclins
C. It is a vasodilator
D. Ithelps in reducing inflammatory aggregate
Clotting time is most like to be prolonged by the administration of ___?
A. Vitamin K
B. Barbiturates
C. Acetominophen
D. Acetyl salicylic acid
Aspirin causes _____?
A. Agranulocytosis
B. Hemolytic anemia
C. Aplastic anemia
D. Hypoprothrombinemia
Prolonged use of aspirin leads to ______?
A. peptic ulcer
B. Bleeding defects
C. Carcinoma
D. A & B
Drug which is used to control status epilepticus is ______?
A. Diazepam
B. Sodium nitroprusside
C. Glyceryl trinitrite
D. Pheno barbital
Drug that does not cause sedation ________?
A. Buspirone
B. Nitrazepam
C. Zopiclone
D. Diazepam
Phenothiazines are used to _____?
A. Produce muscle relaxation
B. Alter psychotic behaviour
C. Suppress coughing
D. Produce analgesia
Thiopentone action is terminated by ______?
A. Excretion
B. Metabolism
C. Redistribution
D. Recycling
Amitryptyline is a __?
A. Antibiotic
B. Sedative
C. Tricyclic antidepressant
D. Diuretic
All of the following decrease skeletal muscle tone by CNS effects except _____?
A. D-tubocurarin
B. Diazepam
C. Beclofen
D. Mephensin
All of the following statements about opioids is correct except ______?
A. Pentazocine and buprinorphine
B. Pentazocine shows withdrawal symptoms in opioid dependent patients
C. Partial agonists are free from classic opioid adverse effects
D. Ethomorphine is similar to pethidine chemically
Phenytoin is associated with _______?
A. Folic acid deficiency
B. Alzhiemer’s disease
C. Cushing’s syndrome
D. Vitamin C deficiency
Which of the following drugs causes extra pyramidal symptoms ___?
A. Antibiotics
B. Salicylates
C. Barbiturates
D. Phenothiazines
Best and most effective drug to control convulsions in toxicity cases is ______?
A. Phenobarbitone
B. Phenytoin
C. Diazepam
D. Carbemezipine
The Ethyl alcohol (Ethanol) is more effective when mixed with water and used as ____?
A. 10 to 20 percent
B. 20 to 30 percent
C. 40 to 50 percent
D. 60 to 70 percent
A patient with grand mal epilepsy would likely be under treatment with ____?
A. Meprobamate
B. Pentobarbital
C. Trimethadione
D. Phenytoin
Birbiturates in pediatrics is _____?
A. Contraindicated
B. Low safety
C. Can be used safely
D. Not much use
Which of the following drugs is currently widely used in treating opioid dependent individuals?
A. codeine
B. Methadone
C. Alphaprodine
D. Pentazocine
Paracetamol is contraindicated in ______?
A. Nephritis
B. Chronic hepatitis
C. Bleeding disorders
D. A & B
The anti-inflammatory analgesic drug the causes least gastrointestinal symptoms is ____?
A. Aspirin
B. Phenyl butazone
C. Paracetamol
D. Indomethacin
Gastric irritation is minimum with one of the following non-steroidal anti inflammatory drugs ____?
A. Piroxicam
B. Tenoxicam
C. Meloxicam
D. Indomethacin
Which of the following is a short acting barbiturate ?
A. Diazepam
B. Secobarbital
C. Pentobarbital
D. Phenobarbita
Aspirin is contraindicated in ______?
A. Peptic ulcer
B. Person suffering form chicken pox or small pox
C. Hemorrhage
D. All of the above
The muscle relaxant effect of succinylcholine lasts for ______?
A. 1 min
B. 2 min
C. 3-5 min
D. 10 min
The rate of injection of intravenous Valium is ______?
A. 1 ml / min
B. 2.5 ml / min
C. 1 mg / min
D. 2.5 mg / min
Ibuprofen is contraindicated in ______?
A. patients having fever
B. patients having asthma
C. patients having amoebic dysentery
D. Patient having bronchitis
Which of the following is a muscle relaxant _______?
A. Scoline
B. Pentazocine
C. Hyoscin
D. Phenylephrine
Activation of which of the following receptors would be expected to decrease anxiety ______?
A. Nicotinic cholinergic receptors
B. Glutamate receptors
C. GABA receptors
D. Glucocorticoid receptors
A Hemophiliac patient has rheumatold arthritis. Which drug might be prescribed to relieve the pain ?
A. Acetaminophen
B. Acetylsalicylic acid
C. Phenylbutazone
D. Naproxen
Folic acid deficiency occurs in _____?
A. Aspirin
B. Phenytoin
C. Chloromphenicol
D. Cyclosporine
An anxiolytic, not interacting with GABA ergic system and used in generalized anxiety is ____?
A. Alprazolam
B. Diazepam
C. Buspiron
D. Phenobarbital
Which among the following may be used as a sedatives hypnotic ?
A. Zolmitriptan
B. Zileuton
C. Zolpiden
D. Zalcitabine
Which among the following is a pure antagonist of opioid receptors ?
A. Natrexone
B. Nalbuphine
C. Butorphanol
D. Pentazonice
DOPA and 5-Hydroxytryptophan are clinically important because _____?
A. They cross blood Brain Barriers
B. They are acidic precursors of Brain amines
C. They act as neuromodulators
D. They are metabolites of various neurogenic amines
The beneficial effect of drug neostigmine in the treatment of Myasthenia gravis is due to the action _____?
A. It is produces more acetylcholine
B. It inhibits the action of cholinesterase
C. It produces more acetycholine receptors
D. It increases the action of cholinesterase
Aspirine is useful in all the following conditions EXCEPT ______?
A. Fever
B. Post myocardial infarction
C. Venous thrombosis
D. Gout
Which among the following Not a pharmacological action of opioids _____?
A. Cough suppression
B. Anti-emesis
C. Miosis
D. Truncal rigidity
Thyroid storm can be treated by all the following drugs EXCEPT ______?
A. Propylthiouracil
B. Dexamethasone
C. Propranolol
D. Aspirin
Which of the following drugs can be given safely to a patient with renal disease ?
A. Phenacetin
B. Tetracycline
C. Aminoglycoside
D. Diazepam
Quinine is obtained from CINCHONA _____?
A. Root
B. Bark
C. Leaves
D. Seed capsule
Read More: Past Papers of Pharmacology