Basic Pharmacology MCQs

Basic Pharmacology mcqs for jobs test preparation in pharmacology departments.

Basic Pharmacology MCQs

When allergic manifestations occur pursuant to use of antimicrobial agents, what of the following is seen ____?

A. Skin eruptions
B. Angioneurotic edema
C. Sialorrhea
D. Serum imbalance
E. Both A & B

Allergic reactions depends on all except ______?

A. previous exposure to the drug
B. Dosage of the drug received
C. Pharmacological action of the drug
D. Antigen antibody reaction

Therapeutic index is ____?

A. LD 100/Ed100
B. ED 100/LD 100
C. LD 50/ED500
D. ED50/LD50

Drugs showing zero order kinetics of elimination _____?

A. Are more common than first order kinetics
B. Decrease in concentration exponentially with time
C. Have a half – life independent of dose
D. Show a plot of drug concentration versus time that is linear

Zero order kinetics is seen with ______?

A. Phenytoin
B. Phenabarbtion
C. Erythromycin
D. Digoxin

Idiosyncracy is known as to have ______?

A. Genetic component
B. Psychological component
C. Psysiological component
D. Nutritional component

Neuro adaptation to drug is same as _______?

A. Physical dependence
B. Psychological dependence
C. Addiction
D. Habituation

Which drugs had high first pass effect ________?

A. Amiodarone
B. Phenytoin
C. Verapamil
D. Disorpyamide

Combination of ampicillin and gentamicin is an example of _____?

A. Indifference
B. Synergy
C. Antagonism
D. Bacterial symbiosis

The phase I reactions of drug metabolism include The following except _____?

A. Hydolysis
B. Reduction
C. Oxidation
D. Conjugation

Drug efficacy refers to _______?

A. Range of disease in which the drug beneficial
B. Maximal intensity of response that can be produced by the drug
C. The therapeutic does range of the drug
D. The therapeutic index of the drug

Intramuscular route is precluded during the medication of ______?

A. Anti-hypertensives
B. Anti-diabetics
C. Anticoagulants
D. Anti-fibrinolytics

For Arsenic poisoning Antidote is _______?

A. Penicillamine
B. E.D.T.A
C. Desferrixamine
D. B.A.L

All the following increases drug metabolism by activating cytochrome enzyme, EXCEPT ______?

A. Tetracycline
B. Cimetidine
C. Rifampicin
D. Phenobarbitone

Loading dose depends on ____?

A. Volume of distribution
B. Clearance
C. Rate of administration
D. Half life

Drugs exhibiting first pass metabolism are all EXCEPT one ______?

A. Morphine
B. Nitroglycerine
C. Propranolol
D. Salicylates

When a drug creates an effect that is unpredictable and unique it is termed as _____?

A. Side effect
B. Toxicity effect
C. Idiosyncratic effect
D. Drug on Drug effect

Drug binds to activate the receptor is same fashion, which directly or indirectly brings effect, is ____?

A. Inverse agonist
B. Antagonist
C. Agonist
D. Partial agonist

According to American society of Anesthetists, physical status scale Class III would be ____?

A. A normal healthy individual
B. A patient with mild systemic disease
C. A patient with severe systemic disease that it not in capacitating
D. None of the above

A drug A & B compared, all are true except _____?

A. 1 mg of A causes same effect of 3 mg of B, so A is more potent
B. 1 mg of A cause effect not even caused by maximum tolerated dose of B, so drug A is more efficacious
C. 1 mg of A cause effect not caused by 1 mg of B so A is more efficacious
D. Efficacy is not dose dependent

Secretory immunoglobulin is _____?

A. IgG
B. IgA
C. IgM
D. IgE

Hepatic first pass metabolism is important in ___?

A. Drugs given IM
B. Drugs taken orally
C. Drugs given IV
D. None of the above

American society of anesthesiologists physical status classification system, P2 is a is a patient who _____?

A. Is healthy
B. With mild systemic disease
C. With severe systemic disease
D. None of the above

The dose of a drug required to produce a specified effect in 50% of the population is _____?

A. Ld50
B. Td50
C. Md50
D. Ed50

The following statements are true about intravenous route of drug administration EXCEPT ______?

A. It is useful in emergencies
B. Aseptic precautions are required
C. Bioavailability is 100%
D. Suspensions can be administered

Teratogenicity results when drugs are given during _____?

A. First trimester
B. Second trimester
C. Third trimester
D. Soon after birth

Therapetic index indicates _____?

A. Drug toxicty
B. Drug potency
C. Drug safety
D. Drug’s Lethal effect

The ratio of the median lethal dose of the median effective dose is the ______?

A. Morbidity index
B. Moratality index
C. Anesthetic ratio
D. Therapeutic index

Km value indicates ______?

A. Purity of Enzyme
B. Physiological role
C. Half life enzymes drug complex
D. Affinity

Plasma concentration of drug at time 0 is 96g/mL. if t1/2 is 2 hours concentration is plasma at 10 hours will be ___?

A. 48
B. 24
C. 12
D. 3

A prodrug is ____?

A. The proto type member of a class of drugs
B. The oldest member of a class of drugs
C. An inactive drug that is transformed in the body to an active metabolite
D. A drug that is stored in body tissues and is then gradually released in the direction

IF patient suffered from exaggerated effect of pharmacological effect ____?

A. Idosyncrasy
B. Toxicity
C. Side effect
D. None of the above

Majority of drugs are transported across the membrane by ____?

A. Passive diffusion
B. Active transport
C. Facilitated trasnsport
D. Filtration

Elimination after 4 half lives in first order kinetics is ______?

A. 84%
B. 93%
C. 80.5%
D. 4.75%

What is the advantage of sublingual route of administration of drugs _____?

A. prevents or bypasses first pass effects
B. Easy to administer
C. Lipid soluble
D. Can be spitted out with signs of toxicity

Drug which crosses placental barrier is _____?

A. phenytoin
B. Diazepam
C. Corticosteroids
D. All of the above

I.V anesthesia is _____?

A. Propofol
B. Sevoflurane
C. Flumazanil
D. Naloxane

Following drug which undergo most of its metabolism presystemically ___?

A. Salbutamol
B. Verapamil
C. Propranolol
D. Paracetamol

Immune mediated qualitative drug intolerance is called ______?

A. Super sensitivity
B. Idiosyncrasy
C. Hyper sensitivity
D. Hyper acidity

Complete drug elimination occurs after how many hours, if t½ is 4 hrs ___?

A. 12 hrs
B. 20 hrs
C. 25 hrs
D. 30 hrs

Which is a prodrug ?

A. Enalapril
B. clonidine
C. Salmeterol
D. Acetazolamide

During administration of NSAIDs in children, the most important of dose administration is _____?

A. Weight of the child
B. Age of child
C. Nature of the drug
D. Chronicity of pain

Read More: Pharmacology Past Paper